| 產(chǎn)品編號 | bs-1505R |
| 英文名稱 | Vasohibin 1 Rabbit pAb |
| 中文名稱 | 血管抑制蛋白1抗體 |
| 別 名 | Vasohibin; KIAA1036; VASH; VASH; VASH1; VASH1_HUMAN; Vasohibin1; Vasohibin-1. |
| 研究領(lǐng)域 | 心血管 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 克 隆 號 | |
| 交叉反應(yīng) | Human,Rat (predicted: Mouse,Rabbit,Pig,Cow,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 41 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human VASH1: 281-365/365 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
VASH1 is a angiogenesis inhibitor. It inhibits migration, proliferation and network formation by endothelial cells as well as angiogenesis. This inhibitory effect is selective to endothelial cells as it does not affect the migration of smooth muscle cells or fibroblasts. It does not affect the proliferation of cancer cells in vitro, but inhibits tumor growth and tumor angiogenesis and acts in an autocrine manner. VASH1 also inhibits artery neointimal formation and macrophage infiltration and exhibits heparin-binding activity. There are two named isoforms. Function: Angiogenesis inhibitor. Inhibits migration,proliferation and network formation by endothelial cells as well asangiogenesis. This inhibitory effect is selective to endothelialcells as it does not affect the migration of smooth muscle cells orfibroblasts. Does not affect the proliferation of cancer cells invitro, but inhibits tumor growth and tumor angiogenesis. Acts in anautocrine manner. Inhibits artery neointimal formation andmacrophage infiltration. Exhibits heparin-binding activity. Subcellular Location: Secreted. Tissue Specificity: Preferentially expressed in endothelial cells. Highly expressed in fetal organs. Expressed in brain and placenta, and at lower level in heart and kidney. Highly detected in microvessels endothelial cells of atherosclerotic lesions. Post-translational modifications: 2 major forms (42 and 36 kDa) and 2 minors (32 and 27 kDa)may be processed by proteolytic cleavage. The largest form (42 kDa)seems to be secreted and the other major form (63 kDa) seems toaccumulate within the cells or pericellular milieu. Polypeptideconsisting of Met-77 to Arg-318 may correspond to the 27 kDa formand that consisting of Met-77 to Val-365 may correspond to the 36kDa form. Similarity: Belongs to the vasohibin family. SWISS: Q7L8A9 Gene ID: 22846 Database links: Entrez Gene: 22846 Human Entrez Gene: 238328 Mouse Omim: 609011 Human SwissProt: Q7L8A9 Human SwissProt: Q8C1W1 Mouse Unigene: 525479 Human Unigene: 216101 Mouse VASH1是一個內(nèi)皮組織衍生的可被血管內(nèi)皮生長因子誘導(dǎo)的分泌性蛋白質(zhì),它是目前為止發(fā)現(xiàn)的唯一以負(fù)反饋為作用機(jī)制調(diào)節(jié)血管新生的因子。它的發(fā)現(xiàn)證實(shí)在血管新生的過程中也存在經(jīng)典的自身調(diào)節(jié)控制機(jī)制—負(fù)反饋調(diào)節(jié)機(jī)制的存在。 |
| 產(chǎn)品圖片 |
Sample:
A431(Human) Cell Lysate at 30 ug
Primary: Anti- Vasohibin 1 (bs-1505R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 41 kD
Observed band size: 41 kD
Sample: Liver（Rat） lysate at 30ug;
Primary: Anti-alpha-Actinin-4 (bs-1505R) at 1:200 dilution;
Secondary: HRP conjugated Goat Anti-Rabbit IgG(bs-0295G-HRP) at 1:3000 dilution;
Predicted band size : 40kD
Observed band size : 40kD
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