| 產(chǎn)品編號 | bs-3892R |
| 英文名稱 | cGMP Rabbit pAb |
| 中文名稱 | 環(huán)磷酸鳥苷抗體 |
| 別 名 | Cyclic GMP; Cyclic guanosine monophosphate; Guanosine 3 5 Cyclic Monophosphate. |
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Specific References (1) | bs-3892R has been referenced in 1 publications.
[IF=9.685] Son, Youlim. et al. Mdm1 ablation results in retinal degeneration by specific intraflagellar transport defects of photoreceptor cells. CELL DEATH DIS. 2022 Sep;13(9):1-12 IF ; Mouse.
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| 產(chǎn)品類型 | 小分子抗體 |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 免疫學(xué) 染色質(zhì)和核信號 信號轉(zhuǎn)導(dǎo) 轉(zhuǎn)錄調(diào)節(jié)因子 藥物及化合物 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 克 隆 號 | |
| 交叉反應(yīng) | cGMP |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 0.34521 kDa |
| 檢測分子量 | |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated cGMP |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Cyclic guanosine monophosphate (cGMP) serves as a second messenger in a manner similar to that observed with cAMP. Peptide hormones, such as the natriuretic factors, activate receptors that are associated with membrane-bound guanylate cyclase (GC). Receptor activation of GC leads to the conversion of GTP to cGMP. Nitric oxide (NO) also stimulates cGMP production by activating soluble GC, perhaps by binding to the heme moiety of the enzyme. Similar to cAMP, cGMP mediates most of its intracellular effects through the activation of specific cGMP dependent protein kinases (PKG). 環(huán)磷酸鳥苷廣泛分布于各種組織中，可激活激活蛋白激酶G（Protein kinase G)；環(huán)磷酸鳥苷含量約為cAMP的1/10～1/100，由鳥苷酸環(huán)化酶催化GTP而生成，被磷酸二酯酶分解。cGMP與cAMP的作用相反，cGMP有乙酰膽堿的作用，抑制心肌收縮力，降低心率，增加神經(jīng)興奮性，刺激白細(xì)胞溶酶體釋放水解酶，刺激淋巴細(xì)胞分裂增殖，抑制糖異生以及興奮副交感神經(jīng)的功能。 cAMP/cGMP（環(huán)磷酸腺苷/環(huán)磷酸鳥苷）是一種環(huán)狀核苷酸，以微量存在于動植物細(xì)胞和微生物中。有人稱其為細(xì)胞內(nèi)的第二信使，而稱激素為“第一信使”。cAMP（或cGMP）由腺苷酸（或鳥苷酸）環(huán)化酶產(chǎn)生，而被磷酸二酯酶降解，因此激活腺苷酸（或鳥苷酸）環(huán)化酶或者抑制磷酸二酯酶可以提高細(xì)胞內(nèi)cAMP（或cGMP）的含量。研究發(fā)現(xiàn)，cAMP（或cGMP）特異性磷酸二酯酶的抑制劑可用于人類疾病的治療。如cAMP的封閉劑，增強(qiáng)β腎上腺素能受體已被用于心率失調(diào)、高血壓、心肌梗死等心臟疾病；cAMP特異性磷酸二酯酶2/4的抑制劑正在進(jìn)行認(rèn)知增強(qiáng)方面的臨床測試；而cGMP特異性磷酸二酯酶類型5可用于治療ED等疾病。因此為篩選出腺苷酸（或鳥苷酸）環(huán)化酶激活劑或磷酸二酯酶抑制劑，需要一個高敏感度、特異性的、可重復(fù)的方案用于檢測cAMP（或cGMP）的濃度。 |
