| 產(chǎn)品編號 | bs-6314R |
| 英文名稱 | NANOS2 Rabbit pAb |
| 中文名稱 | 生殖細(xì)胞增殖相關(guān)蛋白NANOS2抗體 |
| 別 名 | NANO2_HUMAN; Nanos homolog 2; Nanos homolog 2 Drosophila; NANOS2; NOS-2; NOS2. |
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Specific References (1) | bs-6314R has been referenced in 1 publications.
[IF=8.079] Honda Naoto. et al. Roles of microglia/macrophage and antibody in cell sheet transplantation in the central nervous system. STEM CELL RES THER. 2022 Dec;13(1):1-11 IHC ; Mouse.
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| 研究領(lǐng)域 | 細(xì)胞生物 免疫學(xué) 發(fā)育生物學(xué) 信號轉(zhuǎn)導(dǎo) 干細(xì)胞 表觀遺傳學(xué) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 克 隆 號 | |
| 交叉反應(yīng) | Mouse,Rat (predicted: Human) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 15 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human NANOS2: 45-138/138 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Required to support proliferation and self-renewal of proximal germ cells in males only. Probably regulates translation of specific mRNAs by associating with the 3'-UTR of mRNA targets. Essential for spermatogonia formation. Function: Plays a key role in the sexual differentiation of germcells by promoting the male fate but suppressing the female fate.Represses the female fate pathways by suppressing meiosis, which inturn results in the promotion of the male fate. Maintains thesuppression of meiosis by preventing STRA8 expression, which isrequired for premeiotic DNA replication, after CYP26B1 isdecreased. Regulates the localization of the CCR4-NOT deadenylationcomplex to P-bodies and plays a role in recruiting the complex totrigger the degradation of mRNAs involved in meiosis. Required forthe maintenance of the spermatogonial stem cell population. Notessential for the assembly of P-bodies but is required for themaintenance of their normal state (By similarity). Subunit: Interacts with CNOT1, CNOT3, CNOT6L, CNOT7 and CNOT9 (Bysimilarity). Subcellular Location: Cytoplasm. Cytoplasm, P-body (Bysimilarity). Cytoplasm, perinuclear region. Note=Localizes atP-bodies during gonocyte development (By similarity). More abundantin perinuclear region of the cytoplasm of the germ cells of theadult testis. Tissue Specificity: Testis and ovary. Expression found in severalspermatogenic stages: in cells on the periphery of the tubuleswhich could correspond to spermatogonia, in spermatocytes and inround spermatids (at protein level). Similarity: Belongs to the nanos family. Contains 1 nanos-type zinc finger. SWISS: P60321 Gene ID: 339345 Database links: UniProtKB/Swiss-Prot: P60321.1 |
| 產(chǎn)品圖片 |
Sample:
Lane 1: Mouse Testis tissue lysates
Lane 2: Mouse Cerebrum tissue lysates
Lane 3: Rat Testis tissue lysates
Lane 4: Rat Cerebrum tissue lysates
Primary: Anti-NANOS2 (bs-6314R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 15 kDa
Observed band size: 16 kDa
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