| 產(chǎn)品編號 | bs-6413R |
| 英文名稱 | Tetranectin Rabbit pAb |
| 中文名稱 | 四連接素TN抗體 |
| 別 名 | C type lectin domain family 3 member B; C-type lectin domain family 3 member B; Clec3b; Plasminogen kringle 4 binding protein; Plasminogen kringle 4-binding protein; TETN_HUMAN; Tetranectin; TN; TNA. |
| 研究領(lǐng)域 | 腫瘤 心血管 細(xì)胞生物 細(xì)胞骨架 細(xì)胞外基質(zhì) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 克 隆 號 | |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 22, 80 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Tetranectin/CLEC3B/TNA: 51-150/202 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Tetranectin binds to plasminogen and to isolated kringle 4. May be involved in the packaging of molecules destined for exocytosis. Function: Tetranectin binds to plasminogen and to isolated kringle 4. May be involved in the packaging of molecules destined for exocytosis. Subunit: Homotrimer. Subcellular Location: Secreted. Tissue Specificity: Found in plasma. Similarity: Contains 1 C-type lectin domain. SWISS: P05452 Gene ID: 7123 Database links: Entrez Gene: 7123 Human Entrez Gene: 21922 Mouse Omim: 187520 Human SwissProt: P05452 Human SwissProt: P43025 Mouse Unigene: 476092 Human Unigene: 34588 Mouse 四連接素(Tetranectin， TN)是一種血纖維蛋白溶酶原結(jié)合蛋白，可出現(xiàn)在血漿及細(xì)胞外基質(zhì)(extracellular matrix， ECM)。TN除了它的血纖維蛋白溶酶原結(jié)合蛋白特性外，還能與肝磷脂、載脂蛋白(a)，組織纖維蛋白溶酶原激活劑，肝細(xì)胞生長因子及血管他丁。TN的表達(dá)可在各種內(nèi)分泌組織、內(nèi)皮細(xì)胞、及間質(zhì)細(xì)胞檢測到，其中間質(zhì)細(xì)胞包括成纖維細(xì)胞、單核細(xì)胞和中性粒細(xì)胞。血清TN水平的下降可見于創(chuàng)傷后或急性心肌梗塞后，類風(fēng)濕性關(guān)節(jié)炎及惡性腫瘤等。雖然TN的確切生物學(xué)功能未被證實，一些實驗證據(jù)表明TN在組織的修復(fù)重建中起重要的作用。TN可以增加組織型纖維蛋白溶酶原激活劑催化激活纖維蛋白溶酶原以多聚賴氨酸的催化激活作用。因為活化的纖維蛋白溶酶原被公認(rèn)在細(xì)胞外基質(zhì)的退變中起重要作用。 |
