| 產(chǎn)品編號(hào) | bs-13107R |
| 英文名稱(chēng) | esxA Rabbit pAb |
| 中文名稱(chēng) | 結(jié)核分枝桿菌早期分泌抗原esxA/ESAT6抗體 |
| 別 名 | ESXA_MYCTU; 6 kDa early secretory antigenic target; esxA; esaT6; MTV027.10; Rv3875; ESAT-6 protein EsxA; Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv); |
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Specific References (2) | bs-13107R has been referenced in 2 publications.
[IF=4.421] Tomoko Ito. et al. Microbial Antigen-Presenting Extracellular Vesicles Derived from Genetically Modified Tumor Cells Promote Antitumor Activity of Dendritic Cells. Pharmaceutics. 2021 Jan;13(1):57 FC ; Mouse.
[IF=1.64] Koyama, Yoshiyuki, et al. "Exosomes derived from tumor cells genetically modified to express Mycobacterium tuberculosis antigen: a novel vaccine for cancer therapy." Biotechnology Letters (2016): 1-10. IF(ICC) ; Mouse.
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| 研究領(lǐng)域 | 細(xì)胞生物 細(xì)菌及病毒 |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Polyclonal |
| 克 隆 號(hào) | |
| 交叉反應(yīng) | (predicted: Mycobacterium tuberculosis,Mycobacterium szulgai,Mycobacte) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 10 kDa |
| 檢測(cè)分子量 | |
| 細(xì)胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from Mycobacterium tuberculosis ESAT6: 21-95/95 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Mycobacterium tuberculosis is a slow-growing obligate aerobic bacillus that causes most cases of tuberculosis (TB). It is a small, rod-like microbe that can withstand weak disinfectants and survive in a dry state for weeks, but can only grow within a host organism. M. tuberculosis has a thick waxy cell wall that is responsible for the typical caseous granuloma formation in tuberculosis. ESAT6 is a protein secreted by M. tuberculosis that induces a strong immune response in infected organisms, making it a strong candidate for the development of a vaccine against tuberculosis. ESAT6 may also be useful in the detection of the disease. Deletion of the ESAT6 gene leads to the loss of virulence of M. tuberculosis. Function: The ESAT6 antigen from Mycobacterium tuberculosis is a dominant target for cell mediated immunity in the early phase of tuberculosis (TB) in TB patients as well as in various animal models. ESAT6 is not found in M. bovis BCG. Its function is not known but it elicits high level of IFN-gamma from memory effector cells during the first phase of a protective immune response. Subcellular Location: Secreted Similarity: Belongs to the ESAT-6 (esx) family. Database links: Entrez Gene: 886209 MYCTU SwissProt: P9WNK6 MYCTU |
