| 產(chǎn)品編號 | bs-23116R |
| 英文名稱 | NR2E1 Rabbit pAb |
| 中文名稱 | 核受體蛋白NR2E1抗體 |
| 別 名 | NR2E1/Tailless; Tailless; hTll; nr2e1; NR2E1_HUMAN; Nuclear receptor subfamily 2 group E member 1; Nuclear receptor TLX; Orphan nuclear receptor NR2E1; Protein tailless homolog; Tailless homolog; Tll; TLX; XTLL. |
| 研究領(lǐng)域 | 神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo) 干細(xì)胞 表觀遺傳學(xué) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 克 隆 號 | |
| 交叉反應(yīng) | Mouse,Rat (predicted: Human,Rabbit,Pig,Cow,Dog) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 43 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞核 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human NR2E1: 151-250/451 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
NR2 proteins are a large family of nuclear hormone receptor transcription factors. The proteins belonging to this family are characterized by discrete domains functioning in DNA and ligand binding. NR2E1 (nuclear receptor subfamily 2, group E, member 1), also known as TLX, is an essential component in the formation of synaptic plasticity and dendritic structure in retinal astrocytes. In addition, NR2E1 is a orphan receptor that binds DNA as part of the hormone response element (HRE), a transcription regulator for hormones. DNA-binding orphan receptors have the conserved sequence 5'-AAGGTCA-3', a motif that determines substrate binding specificity. NR2E1 is expressed in brain tissue, with highest levels in astrocytes, and is localized to the nucleus. Mutations in the gene that encodes NR2E1 may lead to retinal dystrophy, a disorder characterized by a reduction in the thickness of the retina. Function: Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity. May be required for brain development. May be involved in the regulation of retinal development. Subunit: Monomer (By similarity). Interacts with ATN1; the interaction represses the transcription Subcellular Location: Nucleus. Tissue Specificity: Brain specific. Present in all brain sections tested, highest levels in the caudate nucleus and hippocampus, weakest levels in the thalamus. Similarity: Belongs to the nuclear hormone receptor family. NR2 subfamily. Contains 1 nuclear receptor DNA-binding domain. SWISS: Q9Y466 Gene ID: 7101 Database links: Entrez Gene: 7101 Human Entrez Gene: 21907 Mouse Omim: 603849 Human SwissProt: Q91379 Chicken SwissProt: Q9Y466 Human SwissProt: Q3UXE8 Mouse SwissProt: Q64104 Mouse SwissProt: Q78ZM1 Mouse Unigene: 157688 Human Unigene: 287100 Mouse |
| 產(chǎn)品圖片 |
Sample:
Brain (Mouse) Lysate at 40 ug
Brain (Rat) Lysate at 40 ug
Primary: Anti-NR2E1 (bs-23116R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 43 kD
Observed band size: 43 kD
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