| 產(chǎn)品編號(hào) | bsm-60875R |
| 英文名稱 | ASCL1 Recombinant Rabbit mAb |
| 中文名稱 | 神經(jīng)母細(xì)胞特異性轉(zhuǎn)移因子重組兔單抗 |
| 別 名 | Achaete scute complex homolog 1; MASH1; MASH1/Achaete-scute homolog 1; Achaete scute complex homolog like 1; Achaete scute complex homologue 1; Achaete scute complex homologue like 1; Ascl 1; Ascl1; Ash 1; Ash1; Hash 1; Hash1; Mammalian achaete scute homolog 1; Mammalian achaete scute homologue 1; Mash 1; Achaete-scute homolog 1; ASCL1_HUMAN; ASH-1; hASH1; Class A basic helix-loop-helix protein 46; bHLHa46 |
| 抗體來源 | Rabbit |
| 克隆類型 | Recombinant |
| 克 隆 號(hào) | |
| 交叉反應(yīng) | (predicted: Human) |
| 產(chǎn)品應(yīng)用 | WB=1:500-1000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 26 kDa |
| 檢測(cè)分子量 | |
| 細(xì)胞定位 | 細(xì)胞核 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ASCL1 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene encodes a member of the basic helix-loop-helix (BHLH) family of transcription factors. The protein activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. This protein plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. Mutations in this gene may contribute to the congenital central hypoventilation syndrome (CCHS) phenotype in rare cases. [provided by RefSeq, Jul 2008] Function: Transcriptional regulator. May play a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Involved in the initiation of neuronal differentiation. Mediates transcription activation by binding to the E box (5'-CANNTG-3'). Subunit: Efficient DNA binding requires dimerization with another bHLH protein. Forms a heterodimer with TCF3. Subcellular Location: Nucleus (Probable). Similarity: Contains 1 basic helix-loop-helix (bHLH) domain. SWISS: P50553 Gene ID: 429 Database links: Entrez Gene: 429 Human Entrez Gene: 17172 Mouse Omim: 100790 Human SwissProt: P50553 Human SwissProt: Q02067 Mouse Unigene: 703025 Human Unigene: 136217 Mouse Unigene: 32936 Rat ASCL1/ASH1是一種神經(jīng)母細(xì)胞特異性轉(zhuǎn)移因子,可以促進(jìn)細(xì)胞向一定方向分化但卻抑制了最終的分化環(huán)節(jié),造成細(xì)胞停留于不成熟階段. |
