| 產(chǎn)品編號 | bs-2040R-BF647 |
| 英文名稱 | Rabbit Anti-Atrial natriuretic factor/BF647 Conjugated antibody |
| 中文名稱 | BF647標(biāo)記的心房鈉尿因子/心鈉素/心房利鈉肽抗體 |
| 別 名 | Prepronatriodilatin; ANF_HUMAN; Cardiodilatin; ANF; Atrial natriuretic factor; CDD ANF; CDP; PND; Prepronatriodilatin; Nppa; Natriuretic peptides A; Atrial natriuretic peptide; CDD-ANF; ANP. |
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 心血管 細胞生物 信號轉(zhuǎn)導(dǎo) 激酶和磷酸酶 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse, Rat, (predicted: Human, Dog, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig, ) |
| 產(chǎn)品應(yīng)用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 3/17kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ANP |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: The protein encoded by this gene belongs to the natriuretic peptide family. Natriuretic peptides are implicated in the control of extracellular fluid volume and electrolyte homeostasis. This protein is synthesized as a large precursor (containing a signal peptide), which is processed to release a peptide from the N-terminus with similarity to vasoactive peptide, cardiodilatin, and another peptide from the C-terminus with natriuretic-diuretic activity. Mutations in this gene have been associated with atrial fibrillation familial type 6. [provided by RefSeq, Sep 2009]. Function: Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3. Subunit: Interacts with NPR1. Subcellular Location: Secreted. Post-translational modifications: Cleaved by CORIN upon secretion to produce the functional hormone. DISEASE: Atrial fibrillation, familial, 6 (ATFB6) [MIM:612201]: A familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the natriuretic peptide family. Database links: Entrez Gene: 4878 Human Entrez Gene: 230899 Mouse Omim: 108780 Human SwissProt: P01160 Human SwissProt: P05125 Mouse Unigene: 75640 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 心鈉素（心房利尿鈉肽）：心鈉素主要是由心房分泌的一種含有28個氨基酸并由二硫鍵結(jié)合的一環(huán)形肽分子，具有強大的利鈉、利尿、擴血管等作用。使血管舒張，外周阻力降低；使每博輸出量變少，心率減慢；腎排水排鈉增多；導(dǎo)致體內(nèi)細胞外液量減少。 心鈉素主要來源于心肌纖維，但腦、腎、肺、腎上腺等器官、組織也能表達，但產(chǎn)生及分泌的方式有一定差異。 |
