| 產(chǎn)品編號 | bs-1087R-AP |
| 英文名稱 | Rabbit Anti-Angiopoietin 4/AP Conjugated antibody |
| 中文名稱 | 堿性磷酸酶（AP）標(biāo)記的血管生成素3/血管生成素4抗體 |
| 別 名 | Angiopoietin 4; AGP4; ANG3; ANG-4; ANG 4; ANGPT4; AGP4; ANGP4_HUMAN. ANG 3; ANG-3; ANG3; Angioarrestin; Angiopoietin 3; Angiopoietin like 1; Angiopoietin like protein 1; Angiopoietin related protein 1; Angiopoietin Y1; Angiopoietin-3; Angiopoietin-like protein 1; Angiopoietin-related protein 1; ANGL1_HUMAN; ANGPT3; ANGPTL1; AngY; ARP1; dJ595C2.2; KIAA0351; UNQ162. |
| 規(guī)格價(jià)格 | 100ul/2980元 購買 大包裝/詢價(jià) |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 腫瘤 心血管 免疫學(xué) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, ) |
| 產(chǎn)品應(yīng)用 | WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 54kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ANGPT4 C-terminus |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: Angiopoietin 4 is a glycosylated protein with a fibrinogen C terminal domain. It is induced under hypoxic conditions in endothelial cells and is the target of peroxisome proliferation activators. Angiopoietin 4 is a serum hormone directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity and also acts as an apoptosis survival factor for vascular endothelial cells. It may play a role in several cancers and it also has been shown to prevent the metastatic process by inhibiting vascular activity as well as tumor cell motility and invasiveness. Decreased expression of this protein has been associated with type 2 diabetes. Alternatively spliced transcript variants encoding different isoforms have been described Function: Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis. Subunit: Homodimer; disulfide-linked. Interacts with TEK/TIE2. Subcellular Location: Secreted (Probable). Tissue Specificity: Highly expressed in the lung with much lower levels found in other tissues. Similarity: Contains 1 fibrinogen C-terminal domain. Database links: Entrez Gene: 51378 Human Omim: 603705 Human SwissProt: Q9Y264 Human Unigene: 278973 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 血管生成素4-ANGPTL4與小血管生成、腫瘤的轉(zhuǎn)移有很重要的關(guān)系。 |
