| 產(chǎn)品編號 | bs-15466R-BF488 |
| 英文名稱 | Rabbit Anti-HERV-FRD /BF488 Conjugated antibody |
| 中文名稱 | BF488標(biāo)記的人內(nèi)源性逆轉(zhuǎn)錄病毒膜糖蛋白2抗體 |
| 別 名 | EFRD1_HUMAN; Endogenous retrovirus group FRD member 1; Envelope polyprotein; ERVFRD-1; FLJ41944; FLJ90611; GLLL6191; HERV FRD 6p24.1 provirus ancestral Env polyprotein; HERV FRD; HERV FRD provirus ancestral Env polyprotein; HERV-FRD; HERVFRD; HERVFRD provirus ancestral Env polyprotein; MGC87585; SU; Syncytin 2; Syncytin B; Syncytin-2; TM; Transmembrane protein; UNQ6191; |
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 細(xì)菌及病毒 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, ) |
| 產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 21/37/58kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human HERV-FRD |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has retained its original fusogenic properties. Can make pseudotypes with MLV, HIV-1 or SIV-1 virions and confer infectivity. SU mediates receptor recognition (By similarity). TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity). Subunit: The surface (SU) and transmembrane (TM) proteins form a heterodimer. SU and TM are attached by noncovalent interactions or by a labile interchain disulfide bond (By similarity). Subcellular Location: Virion. Transmembrane protein: Cell membrane; Single-pass membrane protein (Potential). Tissue Specificity: Expressed at higher level in placenta. Expressed at lower level in adrenal, bone marrow, brain, breast, colon, kidney, lung, ovary, peripheral blood lymphocytes, prostate, skin, spleen, testis, thymus, thyroid, trachea. Post-translational modifications: Specific enzymatic cleavages in vivo yield the mature SU and TM proteins (By similarity). The CXXC motif is highly conserved across a broad range of retroviral envelope proteins. It is thought to participate in the formation of a labile disulfide bond possibly with the CX6CC motif present in the transmembrane protein. Isomerization of the intersubunit disulfide bond to an SU intrachain disulfide bond is thought to occur upon receptor recognition in order to allow membrane fusion (By similarity). Similarity: Belongs to the gamma type-C retroviral envelope protein family. HERV class-I FRD env subfamily. Database links: Entrez Gene: 2086 Human SwissProt: P60507 Human SwissProt: P60508 Human SwissProt: P61550 Human SwissProt: P61565 Human SwissProt: P61566 Human SwissProt: P61567 Human SwissProt: P61570 Human SwissProt: Q14264 Human SwissProt: Q69384 Human SwissProt: Q902F8 Human SwissProt: Q902F9 Human SwissProt: Q96L62 Human SwissProt: Q9N2J8 Human SwissProt: Q9N2J9 Human SwissProt: Q9N2K0 Human SwissProt: Q9NX77 Human SwissProt: Q9UKH3 Human SwissProt: Q9UQF0 Human Unigene: 250693 Human Unigene: 406976 Human Unigene: 631996 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
