| 產(chǎn)品編號 | bs-18372R-BF488 |
| 英文名稱 | Rabbit Anti-LRRC26/BF488 Conjugated antibody |
| 中文名稱 | BF488標(biāo)記的富含亮氨酸重復(fù)蛋白26抗體 |
| 別 名 | bA350O14.10; CAPC; cytokeratin-associated protein; Cytokeratin-associated protein in cancer; Leucine-rich repeat-containing protein 26; LRC26_HUMAN; Lrrc26. |
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 免疫學(xué) 神經(jīng)生物學(xué) 細(xì)胞膜受體 細(xì)胞膜蛋白 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, ) |
| 產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 32kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human LRRC26 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: LRRC26 is a 334 amino acid protein that localizes to the cytoplasm and contains six LRR repeats. Expressed at high levels in normal colon, pancreas, prostate, salivary gland and intestine, LRRC26 is also present in several cancer cell lines, including colon cancer and pancreatic cancer, suggesting an important role in carcinogenesis. Function: Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Required for the conversion of BK alpha channels from a high-voltage to a low-voltage activated channel type in non-excitable cells. These are characterized by negative membrane voltages and constant low levels of calcium. Subcellular Location: Membrane. Cytoplasm; cytoskeleton. Although predicted to be a single-pass type I membrane protein, this protein localizes to the cytoplasm when expressed at high levels. Tissue Specificity: Isoform 1 is expressed highly in normal prostate and salivary gland, very weakly in colon, pancreas, and intestine, and not at all in other tissues. Isoform 1 is expressed highly in many cancer cell lines and in breast cancer, pancreatic cancer and colon cancer. Isoform 2 is expressed in cancer cell lines. Similarity: Contains 5 LRR (leucine-rich) repeats. Contains 1 LRRCT domain. Contains 1 LRRNT domain. Database links: Entrez Gene: 389816 Human Omim: 613505 Human SwissProt: Q2I0M4 Human Unigene: 669977 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
