| 產(chǎn)品編號 | bs-5942R |
| 英文名稱 | SERINC3 Rabbit pAb |
| 中文名稱 | 絲氨酸合并蛋白3抗體（腫瘤差異表達(dá)蛋白） |
| 別 名 | TMS 1; TMS-1; AIGP1; DIFF33; SBBI99; serine incorporator 3; TDE; TDE1; Tumor differentially expressed protein 1; SERC3_HUMAN. |
| 研究領(lǐng)域 | 腫瘤 免疫學(xué) 腫瘤細(xì)胞生物標(biāo)志物 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 克 隆 號 | |
| 交叉反應(yīng) | Mouse (predicted: Human,Rat,Rabbit,Cow,Chicken,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 53 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SERINC3: 51-150/473 <Extracellular> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
TDE1, tumor differentially expressed protein 1, is a multi-pass membrane protein also known as serine incorporator 3. Also found on the membranes of the Golgi apparatus within cells, TDE1 is highly expressed in neuronal populations but is also found in thymus, kidney, liver and testis. Expression levels of TDE1 in tumors can be as much as tenfold the amount found in normal tissue of the same type. This increased expression implicates TDE1 as being involved in the cellular transformation from normal to malignant tissue. It is believed TDE1 contributes to oncogenesis by partially protecting cells from serum starvation and etoposide-induced apoptosis. The mechanism through which TDE1 protects cells is poorly understood, but may involve aberrant methylation of TDE1 complexes. Function: May be involved in cellular transformation. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Ubiquitous. Expression levels were increased fourfold to tenfold in lung tumor tissues compared with normal pulmonary tissues. Post-translational modifications: N-glycosylated. Similarity: Belongs to the TDE1 family. SWISS: Q13530 Gene ID: 10955 Database links: Entrez Gene: 10955 Human Entrez Gene: 26943 Mouse Omim: 607165 Human SwissProt: Q13530 Human SwissProt: Q9QZI9 Mouse Unigene: 272168 Human Unigene: 218473 Mouse Unigene: 3775 Rat |
| 產(chǎn)品圖片 |
Sample: Pancreas (Mouse) Lysate at 40 ug
Primary: Anti-SERINC3 (bs-5942R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 53 kD
Observed band size: 53 kD
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