| 產(chǎn)品編號 | bs-12333R |
| 英文名稱 | ERMAP Rabbit pAb |
| 中文名稱 | 紅細(xì)胞膜相關(guān)蛋白ERMAP抗體 |
| 別 名 | ERMAP; ERMAP_HUMAN; Erythroblast membrane associated protein; Erythroid membrane associated protein; Erythroid membrane-associated protein; hERMAP; MGC118810; MGC118811; MGC118812; MGC118813; PRO2801; Radin blood group(Rd); Radin blood group antigen; RD; SC; Scianna blood group(Sc); Scianna blood group antigen. |
| 研究領(lǐng)域 | 細(xì)胞生物 發(fā)育生物學(xué) 信號轉(zhuǎn)導(dǎo) 干細(xì)胞 細(xì)胞膜蛋白 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 克 隆 號 | |
| 交叉反應(yīng) | Human,Mouse,Rat |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,Flow-Cyt=1ug/Test
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 50 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞漿 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ERMAP: 61-120/475 <Extracellular> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
ERMAP is a single-pass type one membrane protein that belongs to the immunoglobulin superfamily. Expressed in cord blood, fetal liver and adult bone marrow, ERMAP is thought to function as a cell adhesion molecule in erythroid cells and is responsible for expression of the Scianna/Radin (Sc/Rd) blood group antigen system. The Sc/Rd system is comprised of seven antigens that are present on the surface of red blood cells and have a variety of functions ranging from protein transport to cell adhesion. These seven blood antigens can differ in their expression within a population and may sometimes differ between mother and child. A fetus expressing different blood antigens than its mother may cause the mother to produce antibodies against the fetal blood. This condition is known as hemolytic disease of the newborn (HDN) and is characterized by jaundice, anemia and in some cases, infant death. Function: Possible role as a cell-adhesion or receptor molecule of erythroid cells. Subcellular Location: Cell membrane. Cytoplasm. Tissue Specificity: Expressed in erythroid-enriched bone marrow (at protein level). Highly expressed in bone marrow and to a lower extent in leukocytes, thymus, lymph node and spleen. Post-translational modifications: Glycosylated. Similarity: Belongs to the immunoglobulin superfamily. BTN/MOG family. Contains 1 B30.2/SPRY domain. Contains 1 Ig-like V-type (immunoglobulin-like) domain. SWISS: Q96PL5 Gene ID: 114625 Database links: Entrez Gene: 114625 Human Entrez Gene: 27028 Mouse Omim: 609017 Human SwissProt: Q96PL5 Human SwissProt: Q9JLN5 Mouse Unigene: 439437 Human Unigene: 290753 Mouse |
