| 產(chǎn)品編號 | bs-11648R-BF488 |
| 英文名稱 | Rabbit Anti-TMEM59L/BF488 Conjugated antibody |
| 中文名稱 | BF488標(biāo)記的跨膜蛋白59樣蛋白抗體 |
| 別 名 | BSMAP; Brain-specific membrane-anchored protein; C19orf4; TM59L_HUMAN; Tmem59l; Transmembrane protein 59-like. |
| 規(guī)格價(jià)格 | 100ul/2980元 購買 大包裝/詢價(jià) |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo) Alzheimer's |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human, (predicted: Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, ) |
| 產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 35kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TMEM59L |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: BSMAP is a 342 amino acid type-I membrane glycoprotein that localizes to organelle membranes and belongs to the TMEM59 family. Expressed at high levels in brain tissue, BSMAP is thought to play a role in brain function and central nervous system activity. The gene encoding BSMAP maps to human chromosome 19, which consists of over 63 million bases, houses approximately 1,400 genes and is recognized for having the greatest gene density of the human chromosomes. It is the genetic home for a number of immunoglobulin (Ig) superfamily members, including the killer cell and leukocyte Ig-like receptors, a number of ICAMs, the CEACAM and PSG family and Fc receptors (FcRs). Function: Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of APP. Inhibits APP transport to the cell surface and further shedding. Subcellular Location: Golgi apparatus membrane. Tissue Specificity: Expressed preferentially at high level in the brain. Post-translational modifications: Belongs to the TMEM59 family. Similarity: Belongs to the TMEM59 family. Database links: Entrez Gene: 25789 Human Entrez Gene: 67937 Mouse SwissProt: Q9UK28 Human SwissProt: Q7TNI2 Mouse Unigene: 329850 Human Unigene: 23002 Mouse Unigene: 203070 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
