| 產(chǎn)品編號(hào) | bs-1189R-AP |
| 英文名稱 | Rabbit Anti-Gastrin/AP Conjugated antibody |
| 中文名稱 | 堿性磷酸酶（AP）標(biāo)記的胃泌素/蛙皮素抗體 |
| 別 名 | Gastrin component II; Gastrin-34; Gastrin 34; Gastrin34; G34; Gastrin component III; Gastrin-17; Gastrin 17; Gastrin17; G17; GAS; GAST; Gastrin precursor; Bombesin; gastrin big; Gastrin-71; Gastrin 71; Gastrin71; Gastrin-52; Gastrin 52; Gastrin52; Big gastrin; Gastrin-14; Gastrin 14; Gastrin14; G14; Gastrin-6; Gastrin 6; Gastrin6; G6; Gastrin; Gastrin component I; G52; GAST_HUMAN. |
| 規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買(mǎi) 大包裝/詢價(jià) |
| 說(shuō) 明 書(shū) | 100ul |
| 研究領(lǐng)域 | 生長(zhǎng)因子和激素 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Rat, (predicted: Human, Mouse, Pig, Rabbit, ) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:50-200 IHC-F=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 2.1/3.9/6/8kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Gastrin |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: Gastrin is mainly known by its first described role as a gastric acid-hormone but the protein also has the ability to promote cellular growth. More recently, gastrin has been suggested to induce leukocyte-endothelial cell interactions and to have a pro-inflammatory effect. Gastrin has two biologically active peptide forms, G34 and G17 and they activate two different receptors: the CCK-1 receptor, which has low affinity for gastrin but high affinity for the related hormone cholecystokinin (CCK), and the CCK-2 receptor, which has high affinity for both gastrin and CCK and mediates the acid-secretory as well as the proliferative effects of gastrin. Function: Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine. Subcellular Location: Secreted. Post-translational modifications: Two different processing pathways probably exist in antral G-cells. In the dominant pathway progastrin is cleaved at three sites resulting in two major bioactive gastrins, gastrin-34 and gastrin-17. In the putative alternative pathway, progastrin may be processed only at the most C-terminal dibasic site resulting in the synthesis of gastrin-71. Sulfation enhances proteolytic processing, and blocks peptide degradation. Levels of sulfation differ between proteolytically-cleaved gastrins. Thus, gastrin-6 is almost 73% sulfated, whereas the larger gastrins are less than 50% sulfated. Sulfation levels are also tissue-specific. Similarity: Belongs to the gastrin/cholecystokinin family. Database links: Entrez Gene: 2520 Human Entrez Gene: 14459 Mouse Omim: 137250 Human SwissProt: P01350 Human SwissProt: P48757 Mouse Unigene: 2681 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Gastrin又稱蛙皮素（Bombesin），是一種含十七個(gè)氨基酸殘基的多肽類激素。它是由胃黏膜產(chǎn)生，可刺激胃液、鹽酸、及消化酶的分泌。Gastrin還可刺激平滑肌收縮、增加血液循環(huán)和胃腸道液體的分泌。 |
